Introduction to molecular evolution. Multiple sequence alignment. Evolutionary models. Approaches to phylogenetic tree reconstruction based on searching algorithms. Character- and distance-based methods. File formats used in phylogenetic analysis. Computational tools to build phylogenetic trees based on nucleotide and amino acid sequences. Ancestral sequence reconstruction. Adaptive evolution. Phylogenetic networks. Phylogenomics.

Brief history of Bioinformatics. Concepts and general characteristics of biological data bases. Bioinformatics applied to structural and functional genomics. Tools and algorithms for nucleotide and aminoacid sequence alignments. Sequence similarity search. Paterns and structural motifs in aminoacid sequences. Phylogenetic analysis, structural protein analysis, and Sistem Biology.